Eleven killed at Karachi's Regent Plaza due to fire
The fire began in the kitchen on the ground floor of the Regent Plaza hotel, before spreading through the building, local media report.
More than 70 people were injured as the fire trapped guests with few escape options, forcing some to fashion makeshift ropes from bedroom sheets.
Several reports said that foreign nationals were among the injured.
Television footage showed knotted lines of sheets hanging from the building's windows.
"We tied the bed sheets together to make a rope, and used that to climb down from the fourth floor," injured man Khalid Mehmood told the AP news agency from his hospital bed.
"We also had to jump mid-way, as the bed sheets weren't long enough."
The Associated Press of Pakistan quoted Karachi mayor, Waseem Akhtar, as saying there had been no emergency exit in the building.
Firefighters rescued other guests from the side of the building with ladders.